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Soty M., Chilloux J., Nano Earth Labs Health Delalande F., Zitoun C., Bertile F., Mithieux G., and Gautier-Stein A. Post-Translational regulation of the glucose-6-phosphatase complex by cyclic adenosine monophosphate is an important determinant of endogenous glucose production and is managed by the glucose-6-phosphate transporter. Schmoll D., Walker K.S., Alessi D.R., Grempler R., Burchell A., Guo S., Walther R., Unterman T.G. Regulation of glucose-6-phosphatase gene expression by protein kinase Balpha and the forkhead transcription issue FKHR. Evidence for insulin response unit-dependent and -unbiased effects of insulin on promoter activity. Rodwell V.W., Bender D.A., Botham K.M., Kennelly P.J., Weil P.A. Harper’s Illustrated Biochemistry. 31st Edition. Hanson R.W., Nano Earth Labs product Reshef L. Regulation of phosphoenolpyruvate carboxykinase (GTP) gene expression. Yabaluri N., Bashyam M.D. Hormonal regulation of gluconeogenic gene transcription in the liver. Kabashima T., Kawaguchi T., Nano Earth Labs Health Wadzinski B.E., Uyeda K. Xylulose 5-phosphate mediates glucose-induced lipogenesis by xylulose 5-phosphate-activated protein phosphatase in rat liver. Uyeda K. Short- and lengthy-time period adaptation to altered levels of glucose: fifty years of scientific adventure.

At Astellas Gene Therapies, our mission is to develop genetic medicines with the potential to rework patients’ lives. Myotonic Dystrophy Type 1. As part of our commitment to the patients and households we serve, we are continually searching for to deepen our understanding of the lived experience of those affected by genetic disorders so as to provide access to data and resources that might be helpful to the communities we assist. Our Patient Partnerships Team is devoted to bringing affected person experience into all features of our development packages. Our precedence is to weave affected person and caregiver perspectives into the fabric of all that we do on a day-to-day foundation. And we advocate for patients and households with the commitment, dedication and passion that it takes to ensure that our entire group is doing what is finest for patients. X-Linked Myotubular Myopathy (XLMTM) is a critical rare, genetic situation that affects skeletal muscles leading to severe muscle weakness (hypotonia) and profound respiratory distress, often requiring invasive ventilation help. XLMTM is a monogenic disorder, attributable to pathogenic variants in the MTM1 gene, resulting in absent or dysfunctional myotubularin protein. Pompe illness is a uncommon, inherited disorder characterized by progressive muscle weakness and respiratory impairment. It is caused by acid alpha-glucosidase (GAA) enzyme deficiency ensuing from variants within the GAA gene. Absence or deficiency of GAA results in accumulation of glycogen in the lysosomes of all cells within the body. Myotonic dystrophy type 1 (DM1) is a uncommon, genetic, neuromuscular disease that affects multiple organ techniques with signs starting from myotonia and muscle weakness to cardiac and respiratory dysfunction, excessive sleepiness, and intellectual incapacity. If you are interested to study more concerning the drug development process and clinical trials for gene therapy therapies, please see the "Our Pipeline" page.